Sodium Hydroxide → 2-butyl-3,5-dihydro-4H-imidazol-4-one

Participants

Reaction Steps

31.71 g (0.25 mol) of glycine methyl ester hydrochloride was added to a solution of 10.1 g (0.25 mol) of sodium hydroxide in methanol at 0° C. After 15 minutes, 126.5 g of a 22.8 percent solution of pentanimidic acid methyl ester in chlorobenzene was instilled for 5 minutes in the white suspension. The light yellow suspension was stirred for 4 hours at room temperature and diluted with chlorobenzene (100 ml). The methanol was distilled off at a temperature of 26° C. and a pressure of 30 to 50 mbar, and the orange suspension was diluted with methylene chloride (100 ml) and then filtered. After removal of the solvent from the filtrate, 34.09 g (97 percent) of the title compound (content>95 percent, according to GC and 1H-NMR) was obtained. Data regarding the product was:

Provenance & Evidence