HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1757511Generated: October 24, 2026
Chloride → 1-Phenyl-3-[3-(4-(dimethylamino)benzyloxy)phenyl]-2-propyne-1-one
https://huagongshe.com/en/reaction/1757511
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloride | HCID 312 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1,3-Diphenyl-2-propyn-1-one | HCID 97637 | — |
| Reactant | 1,3-Diphenyl-2-propyn-1-ol | HCID 296659 | — |
| Reactant | Cornforth reagent | HCID 2724130 | — |
| Reactant | Barium manganate | HCID 3084030 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-Phenyl-3-[3-(4-(dimethylamino)benzyloxy)phenyl]-2-propyne-1-one | HCID 19388218 | — |
Reaction Steps
In step b, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by techniques and procedures well known and appreciated by one of ordinary skill in the art. For example, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by means of either a Swern oxidation (dimethylsulfoxide, oxalyl chloride, and triethylamine), by means of pyridinium dichromate oxidation in a suitable aprotic solvent, such as methylene chloride or by means of barium manganate oxidation in a suitable aprotic solvent, such asmethylene chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05446068 |
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| Source dataset | uspto-grants-1995_08 |
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| ORD ID | ord-33804668c08843c799ea85a43fce2d24 |
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| Source note | uspto-grants-1995_08 |
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