Reaction equation
[C:1]1([C:7]#[C:8][CH:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[OH:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17]1([C:23](=[O:32])C#CC2C=CC=CC=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(Cl)(=O)C(Cl)=O.[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+:48]1[CH:53]=CC=C[CH:49]=1.[NH+]1C=CC=CC=1.[Mn]([O-])([O-])(=O)=O.[Ba+2].[Cl-]>C(Cl)Cl.C(N(CC)CC)C.CS(C)=O>[C:11]1([C:9](=[O:10])[C:8]#[C:7][C:1]2[CH:2]=[CH:3][CH:4]=[C:5]([O:32][CH2:23][C:17]3[CH:22]=[CH:21][C:20]([N:48]([CH3:53])[CH3:49])=[CH:19][CH:18]=3)[CH:6]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1Participants
Reactant 6
Product 1
Reagents, catalysts & solvents 3
Procedure
In step b, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by techniques and procedures well known and appreciated by one of ordinary skill in the art. For example, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by means of either a Swern oxidation (dimethylsulfoxide, oxalyl chloride, and triethylamine), by means of pyridinium dichromate oxidation in a suitable aprotic solvent, such as methylene chloride or by means of barium manganate oxidation in a suitable aprotic solvent, such asmethylene chloride.
Sources & evidence
- ORD record
- ord-33804668c08843c799ea85a43fce2d24
- Source dataset
- uspto-grants-1995_08
- Patent number
- US05446068
Linked notes
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