Potassium Hydroxide → 5-Cyanomethylbenzofuran-2-carboxylic acid

HRID 1758268Notes

Reaction equation

[C:1]([CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]([O:14]CC)=[O:13])=[CH:9][C:8]=2[CH:17]=1)#[N:2].[OH-].[K+]>>[C:1]([CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][C:8]=2[CH:17]=1)#[N:2]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 615261Benzofuran-2-carboxylic acid, 5-cyanomethyl-, ethyl ester

Product 1

HCID 205100445-Cyanomethylbenzofuran-2-carboxylic acid

Procedure

Ethyl 5-cyanomethylbenzofuran-2-carboxylate was hydrolysed by refluxing with ethanolic potassium hydroxide to give 5-cyanomethylbenzofuran-2-carboxylic acid.

Sources & evidence

ORD record: ord-5b49059e561e42be87d28a0bde36211f
Source dataset: uspto-grants-1983_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04372970

Reaction notes

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