Bromine → 3-BROMO-4-(4-FLUOROPHENYL)-4-OXOBUTANOIC ACID
Reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.[Br:15]Br>C(O)(=O)C>[Br:15][CH:8]([C:6](=[O:7])[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:14][CH:13]=1)[CH2:9][C:10]([OH:12])=[O:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3-(4-fluorobenzoyl)propionic acid (0.01 mole) and bromine (0.012 mole) in acetic acid is stirred at room temperature for 16 hours. The solvent is removed to give 3-bromo-3-(4-fluorobenzoyl)propionic acid.
Workup
- customThe solvent is removed
Sources & evidence
- ORD record
- ord-2ff560a2c66e40ed954266db1761ee30
- Source dataset
- uspto-grants-1983_02
- Patent number
- US04374249
Reaction notes
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