Sodium Hydroxide → 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline

HRID 1758703

Reaction equation

HRID 1758703 reaction equation
Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6]1.[C:18]1([S:24][CH2:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[OH-].[Na+]>>[C:18]1([S:24][CH2:25][CH2:26][CH2:27][N:28]2[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][N:5]3[C:14]4[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=4[N:7]=[CH:6]3)[CH2:30][CH2:29]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 760117-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dioneHCID 21954921-(3-(Phenylthio)propyl)piperazine

Product 1

HCID 30617397-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline

Procedure

7-(3-Chloropropyl)-theophylline (1 mole) and 1-(3-phenylthiopropyl)-piperazine are refluxed for 24 hours in a 50% aqueous-alcoholic solution. On completion of the reaction, sodium hydroxide (1 mole) is then added. The mixture is extracted with methylene chloride and washed with water, after which the solvent is evaporated off and the residue is recrystallized from ethanol.

Workup

  1. additionis then added
  2. extractionThe mixture is extracted with methylene chloride
  3. washwashed with water
  4. customafter which the solvent is evaporated off
  5. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-ff943f179a204bf99252551d0e6d29af
Source dataset
uspto-grants-1983_02
Patent number
US04374835

Linked notes

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