HCID 12803422, compound → 1-(2-Methoxyethyl)-4-phenylimidazolidin-2-one
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:16]>[Pd].C(O)C>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[NH:7][C:6]1=[O:16]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The 1-(2-methoxyethyl)-4-phenyl-4-imidazolin-2-one (6.5 g) so obtained is next admixed with 10% palladium on carbon (0.7 g) in ethanol (50 ml). The mixture is thereafter hydrogenated at 50 psi at room temperature for four hours and the catalyst is filtered. Resultant filtrate is finally concentrated to yield racemic 1-(2-methoxyethyl)-4-phenyl-2-imidazolidone (6.0 g), [α]D20 =-0.2(c=1 in CHCl3).
Workup
- filtrationthe catalyst is filtered
- concentrationResultant filtrate is finally concentrated
Sources & evidence
- ORD record
- ord-7cec78dbd0884ea285c883ff0da02de3
- Source dataset
- uspto-grants-1982_07
- Patent number
- US04339603
Reaction notes
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