Acetic Acid → 110714-14-2
Reaction equation
[N:1]1([C:6]2[N:11]=[N:10][C:9](Cl)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)(=[O:15])C>>[N:1]1([C:6]2[CH:7]=[CH:8][C:9](=[O:15])[NH:10][N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1Participants
3
Procedure
9.93 g (0.055 mole) of 6-(1-imidazolyl)-3-chloropyridazine [prepared according to J. Med. Chem. 24, 59 (1981)] are boiled with 7.7 g (0.0781 mole) of fused potassium acetate in 114 ml of acetic acid under reflux for 10 hours and then evaporated to dryness under reduced pressure. The residue is taken up in 200 ml of chloroform, the precipitate is filtered off, washed 4 times with water, then with ether and diisopropyl ether and dried to give 4.9 g (55% yield) of the aimed product, m. p. 239°-240° C.
Workup
- temperatureunder reflux for 10 hours
- customevaporated to dryness under reduced pressure
- filtrationthe precipitate is filtered off
- washwashed 4 times with water
- dry with materialwith ether and diisopropyl ether and dried
Sources & evidence
- ORD record
- ord-63859f0fee8a463687f86b608effa81c
- Source dataset
- uspto-grants-1989_05
- Patent number
- US04826845
Reaction notes
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