Acetic Anhydride → N-(3-Chloro-4-fluorophenyl)acetamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 3-chloro-4-fluoroaniline (100 g) was slowly added acetic anhydride (200 ml). After allowed to stand for 30 minutes, the reaction mixture was poured into water (1 litter). The resulting precipitate was collected by filtration and recrystallized from aqueous ethanol to give the title compound (119.4 g), mp 118°-119° C.
Workup
- filtrationThe resulting precipitate was collected by filtration
- customrecrystallized from aqueous ethanol
Sources & evidence
- ORD record
- ord-5e5001753cee4cfdbeb924443d6973e6
- Source dataset
- uspto-grants-1989_05
- Patent number
- US04826982
Reaction notes
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