Ammonia → HCID 10997097, compound

Reaction equation

[CH2:1]([N:4]([C:10]([O:12]C)=O)[CH2:5][C:6](OC)=[O:7])[C:2]#[CH:3].[NH3:14]>>[CH2:1]([N:4]1[CH2:5][C:6](=[O:7])[NH:14][C:10]1=[O:12])[C:2]#[CH:3]

Participants

Reactant 2

HCID 222Ammonia

HCID 14580243HCID 14580243, compound

Product 1

HCID 10997097HCID 10997097, compound

Procedure

3.0 g of methyl N-propargyl-N-methoxycarbonylglycinate were dissolved in 40 ml of 28% aqueous ammonia. Then the mixture was maintained under the pressure of 10-13 kg/cm2 at 100°-110° C. for an hour. Then the solvent was evaporated off from the reaction mixture. The resulting mixture was subjected to a column chromatography on silica gel (5:1 ethyl acetate:methanol as eluent) to obtain 0.65 g of 1-propargyl-2,4-dioxoimidazolidine.

Workup

temperatureThen the mixture was maintained under the pressure of 10-13 kg/cm2 at 100°-110° C. for an hour
customThen the solvent was evaporated off from the reaction mixture

Sources & evidence

ORD record: ord-4f522af51f2d43db858a99d16f8429f9
Source dataset: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04827020

Reaction notes

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