Ammonia → HCID 21242407, compound

Reaction equation

[CH2:1]([N:4]([C:10]([O:12][CH3:13])=[O:11])[CH2:5][C:6](OC)=O)[C:2]#[CH:3].[NH3:14].C[OH:16]>>[CH2:1]([N:4]([C:10]([O:12][CH3:13])=[O:11])[C:5](=[O:16])[CH2:6][NH2:14])[C:2]#[CH:3]

Participants

Reactant 3

HCID 222Ammonia

HCID 887Methanol

HCID 14580243HCID 14580243, compound

Product 1

HCID 21242407HCID 21242407, compound

Procedure

3.9 g of methyl N-propargyl-N-methoxycarbonylglycinate were added to the mixture of 100 ml of 28% aqueous ammonia and 10 ml of methanol and stirred for 10 hours at room temperature. Then the solvent was evaporated off from the reaction mixture. The residue was chromatograhed on silica gel to obtain 3.0 g of N-propargyl-N-methoxycarbonylglycinamide (melting point: 77°-80° C.).