Methanol → Ethyl 2-(4-amino-3-(cyclopropylmethoxy)phenyl)acetate

Reaction equation

[CH3:21][OH:22].[CH:1]1([CH2:4][O:5][c:6]2[cH:7][c:8]([CH2:15][C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:9][cH:10][c:11]2[N+:12]([O-:13])=[O:14])[CH2:2][CH2:3]1.[OH-:23].[OH-:24].[Pd+2:25]>>[CH:1]1([CH2:4][O:5][c:6]2[cH:7][c:8]([CH2:15][C:16](=[O:17])[O:18][CH2:19][CH3:20])[cH:9][cH:10][c:11]2[NH2:12])[CH2:2][CH2:3]1

Participants

Reactant 4

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 57995474Ethyl 2-(3-(cyclopropylmethoxy)-4-nitrophenyl)acetate

Product 1

HCID 57995628Ethyl 2-(4-amino-3-(cyclopropylmethoxy)phenyl)acetate

Sources & evidence

ORD record: ord-d152b7e85730486eacc97368646f5edc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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