3-(Methylsulfanyl)propanenitrile → HCID 178458073, compound

HRID 1762976

Reaction equation

HRID 1762976 reaction equation
CSCCC#N.C1SC(NC(N)=N)=NC=1CS[CH2:18][CH2:19][C:20]([NH:22][S:23]([NH2:26])(=[O:25])=[O:24])=[NH:21]>>[S:23]([NH:22][C:20](=[NH:21])[CH:19]=[CH2:18])(=[O:25])(=[O:24])[NH2:26]

Participants

3

Reactant 2

HCID 5483863-(Methylsulfanyl)propanenitrileHCID 178418935HCID 178418935, compound

Product 1

HCID 178458073HCID 178458073, compound

Procedure

N-sulfamyl-acrylamidine was prepared by a four-step procedure from 3-(methylthio)-propionitrile, with an extremely low (5.5%) yield in several days. The products of the subsequent steps, including famotidine, were isolated by column chromatography.

Workup

  1. customyield in several days
  2. customwere isolated by column chromatography

Sources & evidence

ORD record
ord-09fcdf6f02f84672bde87c942a1f3963
Source dataset
uspto-grants-1989_05
Patent number
US04835281

Linked notes

Loading…