Acetohydrazide → 3-Methyl-6-(o-fluorophenyl)-1,2,4-triazolo-[4,3-b]pyridazine
Reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])=[CH:6][CH:7]=1.[C:15]([NH:18][NH2:19])(=O)[CH3:16]>C(O)CCC>[CH3:16][C:15]1[N:3]2[N:4]=[C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[F:14])[CH:6]=[CH:7][C:2]2=[N:19][N:18]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
As in Example 36, a mixture of 2.5 g. of 3-chloro-6-(o-fluorophenyl)-pyridazine and 1.76 g. of acetylhydrazine in 50 ml. of n-butanol is refluxed for 48 hrs. to give 2.0 g. of product as off-white crystals, m.p. 147°-149° C.
Workup
- additionAs in Example 36, a mixture of 2.5 g
- customto give 2.0 g
Sources & evidence
- ORD record
- ord-e33034c14a694ea8907693d91868e635
- Source dataset
- uspto-grants-1978_09
- Patent number
- US04112095
Reaction notes
Loading…