Sodium Hydroxide → HCID 20307400, compound

Temperature

100 °C

The diethylacetal of 2-bromoacetaldehyde (40 grams) and 1,4-dimethylpentylamine (50 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at a temperature of about 100° C. for a period of about 3 hours. After this time sodium hydroxide (10 grams) dissolved in water (100 ml) was added and the resulting mixture stirred for about 30 minutes. The reaction mixture was then extracted with ether. The ether extract was separated, dried over magnesium sulfate, filtered and stripped of solvent under reduced pressure to yield the desired product the diethylacetal of 2-(1,4-dimethylpentylamino)acetaldehyde having a boiling point of 95° C. at 1 mm of Hg pressure.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. additionwas added
4. extractionThe reaction mixture was then extracted with ether
5. extractionThe ether extract
6. customwas separated
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered

ORD record

ord-dd0ee538c13e454d8bc039c1439d89ca

Source dataset

uspto-grants-1978_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04113464