Acetic Anhydride → 1-[4-Phenyl-3-(4H-1,2,4-triazol-4-yl)-1H-pyrazol-1-yl]ethan-1-one
Reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][NH:10][C:11]=2[N:12]2[CH:16]=[N:15][N:14]=[CH:13]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([N:9]1[CH:8]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:11]([N:12]2[CH:13]=[N:14][N:15]=[CH:16]2)=[N:10]1)(=[O:19])[CH3:18]Participants
3
Procedure
A suspension of 4-(4-phenyl-5-pyrazolyl)-4H-1,2,4-triazole (1.0 g) in acetic anhydride is refluxed until a clear solution is obtained. The solution is poured into ice water and stirred for 1/2 hour. The yellowish solid is collected and recrystallized from a mixture of chloroform/hexane, giving a white powder, m.p. 165° C to 168° C. Similarly prepared is the propionyl derivative.
Workup
- temperatureis refluxed until a clear solution
- customis obtained
- customThe yellowish solid is collected
- customrecrystallized from a mixture of chloroform/hexane