2,5-Difluoronitrobenzene → Methyl 2-(4-fluoro-2-nitroanilino)-5-phenyl-thiophene-3-carboxylate

HRID 1764280

Reaction equation

HRID 1764280 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].F[C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=1[N+:25]([O-:27])=[O:26]>C(Cl)Cl>[F:24][C:21]1[CH:22]=[CH:23][C:18]([NH:1][C:2]2[S:3][C:4]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:5][C:6]=2[C:7]([O:9][CH3:10])=[O:8])=[C:19]([N+:25]([O-:27])=[O:26])[CH:20]=1

Participants

4

Reactant 2

HCID 677672,5-DifluoronitrobenzeneHCID 705256Methyl 2-amino-5-phenylthiophene-3-carboxylate

Product 1

HCID 20387675Methyl 2-(4-fluoro-2-nitroanilino)-5-phenyl-thiophene-3-carboxylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methyl 2-amino-5-phenyl-thiophene-3-carboxylate and 2,5-difluoronitrobenzene, m.p. 150° C. (CH2Cl2).

Sources & evidence

ORD record
ord-a62b0c57f444414685e5a1f65c1766ec
Source dataset
uspto-grants-1978_09
Patent number
US04115574

Linked notes

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