Pyridinium chloride → 2-n-Butyl-3-(4-hydroxyphenylsulfonyl)benzofuran

Reaction equation

[CH2:1]([C:5]1[O:6][C:7]2[CH:24]=[CH:23][CH:22]=[CH:21][C:8]=2[C:9]=1[S:10]([C:13]1[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH2:2][CH2:3][CH3:4].Cl.N1C=CC=CC=1>>[CH2:1]([C:5]1[O:6][C:7]2[CH:24]=[CH:23][CH:22]=[CH:21][C:8]=2[C:9]=1[S:10]([C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 227689052-n-Butyl-3-(4-methoxyphenylsulfonyl)benzofuran

Product 1

HCID 149563642-n-Butyl-3-(4-hydroxyphenylsulfonyl)benzofuran

Procedure

2-n-Butyl-3-(4-methoxyphenylsulfonyl)benzofuran was demethylated with pyridine hydrochloride at 185° according to the procedure described in Example 1 to give 2-n-butyl-3-(4-hydroxyphenylsulfonyl)benzofuran, m.p. 163°-165°.

Sources & evidence

ORD record: ord-41f5c74c15cc4c1ebb28072e7e8eab50
Source dataset: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04117128

Reaction notes

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