Methanol → HCID 178478705, compound
Reaction equation
[ClH:1].Cl.[NH2:3][CH2:4][C:5]([C:7]1[N:8]=[CH:9][N:10](CC2C=CC=CC=2)[C:11]=1[NH2:12])=[O:6].CO.O.[H][H]>[Pd].C(O)(=O)C>[ClH:1].[ClH:1].[NH2:3][CH2:4][C:5]([C:7]1[N:8]=[CH:9][NH:10][C:11]=1[NH2:12])=[O:6]Participants
7
Reactant 4
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 1.0 g. of 2-amino-1-[5-amino-1-(phenylmethyl)-1H-imidazol-4-yl]ethanone dihydrochloride in 100 ml. of 70:20:10 methanol:water:acetic acid is hydrogenated over 0.52 g. of 20% palladium-on-carbon at 50 p.s.i. until hydrogen uptake ceases. The catalyst is removed by filtration and the filtrate is evaporated at reduced pressure to give 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone dihydrochloride; m.p. above 250° dec.
Workup
- customThe catalyst is removed by filtration
- customthe filtrate is evaporated at reduced pressure
Sources & evidence
- ORD record
- ord-707a4ff2625348feb1ccf816c8d30369
- Source dataset
- uspto-grants-1978_09
- Patent number
- US04117229
Reaction notes
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