3-Pyrrolidone, 1-methyl- → n-{4-Methyl-3-[(4-(3-pyridyl)pyrimidin-2-yl)amino]phenyl}{4-[(1-methylpyrrolidin-3-yl)amino]phenyl}carboxamide

Participants

Reaction Steps

The above nitro compound was hydrogenated under hydrogen atomosphere in EtOH for 1 hour and filtered through Celite. To the solution was added NaBHCN (1.3 eq) and 1-methyl-3-pyrrolidinone (1 eq), the reaction was stirred at RT overnight and evaporated in vacuo and further purified by flash chromatography on silica gel afforded title compound. Mass: (M+1), 480.

Provenance & Evidence