Ethanol → Ethyl 3-Bromo-5-fluorobenzoate
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:11])[CH:10]=1)[C:5]([OH:7])=[O:6].[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O>[CH2:12]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([F:11])[CH:10]=[C:2]([Br:1])[CH:3]=1)[CH3:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
Sulphuric acid (5 drops) was added to 3-bromo-5-fluorobenzoic acid (1.194 g, 5.45 mmol) in ethanol (10 ml) and refluxed with stirring at 90° C. for 17 hours. Reaction mixture partitioned between diethyl ether and water, washed with sodium hydrogen carbonate, dried (MgSO4) and evaporated to dryness.
Workup
- temperaturerefluxed
- customReaction mixture
- custompartitioned between diethyl ether and water
- washwashed with sodium hydrogen carbonate
- dry with materialdried (MgSO4)
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-e896d59eecb94405a6fb45a596741757
- Source dataset
- uspto-grants-2007_06
- Patent number
- US07232821B2
Reaction notes
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