6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → (RS)-2-oxo-1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid

HRID 1768142

Reaction equation

HRID 1768142 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:17]=[CH:16][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.CC1(C)[O:28][C:27](=O)[C:24]2([CH2:26][CH2:25]2)[C:23](=[O:30])[O:22]1>>[O:28]=[C:27]1[CH:24]([C:23]([OH:30])=[O:22])[CH2:25][CH2:26][N:15]1[C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]2[CH:16]=[CH:17][C:3]([C:2]([F:18])([F:19])[F:1])=[CH:4][CH:5]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 221378894-(4-Trifluoromethyl-benzyloxy)-phenylamine

Product 1

HCID 23614753(RS)-2-oxo-1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid

Procedure

The title compound is prepared in analogy to Example 3c) from 4-(4-trifluoromethyl-benzyloxy)-phenylamine and 6,6-dimethyl-5,7-dioxa-spiro[2,5]octane-4,8-dione. Yield: 37% of a colorless solid. MS: m/e=380.1 (M+H)+.

Sources & evidence

ORD record
ord-e82aceb8b5e7496b8dca613177d52431
Source dataset
uspto-grants-2007_06
Patent number
US07235581B2

Linked notes

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