(S)-4-(6-(5-fluoropyridin-3-yl)-2-(methylthio)pyrimidin-4-yl)-3-methylmorpholine → (S)-1-(3-fluoro-4-(4-(5-fluoropyridin-3-yl)-6-(3-methylmorpholino)pyrimidin-2-yl)phenyl)-3-(2-fluoroethyl)urea
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12](SC)[N:11]=[C:10]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][C@@H:17]3[CH3:22])[CH:9]=2)[CH:5]=[N:6][CH:7]=1.ClC1N=C(N2CCOC[C@@H]2C)C=C(C2C=NC=C(F)C=2)N=1.[F:44][C:45]1[CH:46]=[C:47]([NH:60][C:61]([NH:63][CH2:64][CH2:65][F:66])=[O:62])[CH:48]=[CH:49][C:50]=1B1OC(C)(C)C(C)(C)O1>>[F:44][C:45]1[CH:46]=[C:47]([NH:60][C:61]([NH:63][CH2:64][CH2:65][F:66])=[O:62])[CH:48]=[CH:49][C:50]=1[C:12]1[N:13]=[C:8]([C:4]2[CH:5]=[N:6][CH:7]=[C:2]([F:1])[CH:3]=2)[CH:9]=[C:10]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][C@@H:17]2[CH3:22])[N:11]=1Participants
4
