2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 131734178, compound
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12](=[O:13])[NH:11][N:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:14][Si:15]([CH2:18][CH2:19][O:20][CH2:21]Cl)([CH3:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[N:11]([CH2:21][O:20][CH2:19][CH2:18][Si:15]([CH3:17])([CH3:16])[CH3:14])[N:10]=[N:9]2)=[CH:6][CH:7]=1Participants
3
Procedure
Compound 14a (5.00 g, 20.7 mmol) was treated with SEMCl using the reaction conditions described in Example 10, Step C to obtain compound 14b as a white solid (6.90 g, 81% yield). Mass Spectrum (LCMS, ESI pos.): Calcd. for C13H19BrN4O2Si: 371.0 (M+H). Found 371.1.
Workup
- customthe reaction conditions
Sources & evidence
- ORD record
- ord-e6d8628660f44cc88b9417a5057bca3b