2-(Azetidin-3-yl)quinoline → HCID 117728045, compound

Reaction equation

Cl[C:2]1[N:3]=[C:4]2[C:9]([N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)=[N:8][CH:7]=[CH:6][N:5]2[CH:16]=1.[NH:17]1[CH2:20][CH:19]([C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[N:22]=2)[CH2:18]1>>[N:22]1[C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:29]=[CH:30][C:21]=1[CH:19]1[CH2:18][N:17]([C:2]2[N:3]=[C:4]3[C:9]([N:10]4[CH2:15][CH2:14][O:13][CH2:12][CH2:11]4)=[N:8][CH:7]=[CH:6][N:5]3[CH:16]=2)[CH2:20]1

Participants

Reactant 2

HCID 585484432-(Azetidin-3-yl)quinoline

HCID 117727948HCID 117727948, compound

Product 1

HCID 117728045HCID 117728045, compound

Procedure

Compound 25a was prepared from compound 24a and compound 24d using the procedure described in Example 24, Step E. Mass Spectrum (LCMS, ESI pos.) Calcd. For C22H22N6O: 387.2 (M+H). Found 387.2.

Sources & evidence

ORD record: ord-09c26c05810c402699ecb02a17ee2af7
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09249163B2

Reaction notes

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