Sodium Hydroxide → 2-(Trityloxy)acetic acid
Reaction equation
[C:1]([O:20][CH2:21][C:22]([O:24]CC)=[O:23])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CCO>[C:1]([O:20][CH2:21][C:22]([OH:24])=[O:23])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension of ethyl 2-(trityloxy)acetate (8.2 g, 23.67 mmol) in EtOH (350 ml), NaOH 6M (7.89 ml, 47.3 mmol) was added at RT. The suspension slowly turned into a solution. After 1 hour, EtOH was removed under vacuum and the remaining crude was partitioned between HCl 2N and DCM. The organic phase was separated, dried over Na2SO4 and evaporated under vacuum. 2-(Trityloxy)acetic acid was obtained (7.42 g, 23.31 mmol, 98% yield) and used as such in the following reaction without further purification.