Sodium Hydroxide → 4-Chloro-2-(1H-pyrazol-3-yl)phenol
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6](/[CH:8]=[C:9](\C)/[CH:10]=O)[CH:7]=1.CC1C=CC(S([NH:24][NH2:25])(=O)=O)=CC=1.[OH-].[Na+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]([C:8]2[CH:9]=[CH:10][NH:25][N:24]=2)[CH:7]=1Participants
5
Procedure
A mixture of (E)-3-(5-chloro-2-hydroxyphenyl)-2-methylacrylaldehyde (40 mg, 0.203 mmol) and 4-methylbenzenesulfonohydrazide (41.7 mg, 0.224 mmol) in Acetonitrile (3 mL) were stirred at room temperature for 3 h and then acetonitrile (2 mL), Sodiumhydroxide (8.95 mg, 0.224 mmol) were added and the mixture was heated at reflux for 16 h. Product was used for further reaction without purification.
Workup
- temperaturethe mixture was heated
- temperatureat reflux for 16 h
- customProduct was used for further reaction without purification
Sources & evidence
- ORD record
- ord-e93c3bc0b808426aa4568fbd3d4bdadd
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09266838B2
Reaction notes
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