2-Bromo-3-fluorobenzaldehyde → HCID 131734822, compound
Reaction equation
[CH3:1][O:2][C:3]([C:5]1[C@H:6](C2C=CC(F)=CC=2Cl)[N:7]=[C:8]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)[NH:9][C:10]=1[CH2:11][Br:12])=[O:4].[Br:26][C:27]1[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:28]=1C=O>>[Br:26][C:27]1[C:34]([F:35])=[CH:33][CH:32]=[CH:31][C:28]=1[C@H:6]1[C:5]([C:3]([O:2][CH3:1])=[O:4])=[C:10]([CH2:11][Br:12])[NH:9][C:8]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[N:7]1Participants
3
Procedure
Methyl (4R)-4-(2-bromo-3-fluoro-phenyl)-6-(bromomethyl)-2-thiazol-2-yl-1,4-dihydropyrimidine-5-carboxylate 94a was prepared in analogy to compound C with procedures shown in Example 1 by using 2-bromo-3-fluorobenzaldehyde instead of 2-chloro-4-fluoro-benzaldehyde.
Sources & evidence
- ORD record
- ord-5d8dcee950034a81b13fed2e6df68fe1
- Source dataset
- uspto-grants-2016_02
- DOI