2-Aminopropanol → 5-Bromo-2-(2-hydroxy-1-methylethyl)isoindolin-1-one

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O-:8])=O)=[C:4]([CH2:11]Br)[CH:3]=1.[NH2:13][CH:14]([CH3:17])[CH2:15][OH:16]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:9][CH:10]=1)[C:6](=[O:8])[N:13]([CH:14]([CH3:17])[CH2:15][OH:16])[CH2:11]2

Participants

Reactant 2

HCID 51262-Aminopropanol

HCID 231581454-Bromo-2-(bromomethyl)benzoate

Product 1

HCID 231582825-Bromo-2-(2-hydroxy-1-methylethyl)isoindolin-1-one

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 52, Step 6 starting from 4-bromo-2-(bromomethyl)benzoate and 2-aminopropanol (Aldrich Cat No. 192171). LCMS (M+H)+=270.1.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-96d4bab3cf9b4ceab24ecdb9257830b6
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09266892B2

Reaction notes

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