Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → HCID 67592430, compound
Reaction equation
[CH2:1]([CH:3]1[NH:7][C:6](=O)[CH2:5][CH:4]1[CH3:9])C.F[B-](F)(F)F.[CH3:15][O+:16]([CH3:18])C>C(Cl)Cl>[NH:7]([CH:3]1[CH:1]=[C:15]([O:16][CH3:18])[CH2:5][CH:4]1[CH3:9])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 0.254 g (2 mmol) of 5-ethyl-4-methyl-2-pyrrolidone (from step B) in 3 mL of CH2Cl2 was added 0.355 g (2.4 mmol) of trimethyloxonium tetrafluoroborate under a N2 atmosphere. After stirring overnight the reaction mixture was quenched with saturated K2CO3 solution and diluted with Et2O. The solution was filtered and the filtrate was concentrated. The residue was purified by flash chromatography using Et2O-hexane to isolate 0.224 g (79%) of the title compound.
Workup
- customwas quenched with saturated K2CO3 solution
- additiondiluted with Et2O
- filtrationThe solution was filtered
- concentrationthe filtrate was concentrated
- customThe residue was purified by flash chromatography
Sources & evidence
- ORD record
- ord-f48a6e7dc22546ea8439a5549e0809a6
- Source dataset
- uspto-grants-1997_05
- Patent number
- US05629322
Reaction notes
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