Ethyl 4-methylidenecyclohexane-1-carboxylate → 4-Methylenecyclohexylmethanol
Reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][C:9](=[CH2:12])[CH2:8][CH2:7]1)=O)C.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH2:12]=[C:9]1[CH2:10][CH2:11][CH:6]([CH2:4][OH:3])[CH2:7][CH2:8]1Participants
3
Procedure
The reduction reaction of 4-methylene-cyclohexanecarboxylic acid ethyl ester with LAH is as described in the above reference. The product was purified by distillation to provide (4-methylene-cyclohexyl)-methanol as clear oil (3.67 g, 29.09 mmol, 50% over Step A and B).
Workup
- distillationThe product was purified by distillation
Sources & evidence
- ORD record
- ord-bd9245b2f7094d11a58f50b566c68df3
- Source dataset
- uspto-grants-2009_03
- Patent number
- US07501408B2
Reaction notes
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