2-Amino-5-chlorobenzenesulphonamide → 7-Chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

HRID 17844

Reaction equation

HRID 17844 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH:13]([O-])([O-])OCC>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][CH:13]=[N:12][S:9](=[O:11])(=[O:10])[C:3]=2[CH:4]=1

Participants

3

Reactant 2

HCID 122955502-Amino-5-chlorobenzenesulphonamideHCID 53630039Ethylorthoformate

Product 1

HCID 100362767-Chloro-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

Procedure

A mixture of 2-amino-5-chlorobenzenesulphonamide (obtained according to J. Chem. Soc. Perkin I, 1043-1047, 1979) and ethyl orthoformate (40 mL) is heated at boiling for 30 minutes in an open vessel. The volume of the mixture is reduced by half under reduced pressure. The precipitate obtained is collected by filtration, washed with ether and dried.

Workup

  1. temperatureis heated
  2. customThe precipitate obtained
  3. filtrationis collected by filtration
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-6b717345c1614eb9a2a1a77154c00af2
Source dataset
uspto-grants-2010_06
Patent number
US07741320B2

Linked notes

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