Chlorosulfonic acid → HCID 86601723, compound
Reaction equation
[Cl:1][S:2]([OH:5])(=O)=[O:3].[CH2:6]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH2:15][N:14]([C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])[CH2:13][CH2:12]2)[CH3:7]>ClCCl>[CH2:6]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][C:18]=1[S:2]([Cl:1])(=[O:5])=[O:3])[CH2:15][N:14]([C:19](=[O:24])[C:20]([F:21])([F:22])[F:23])[CH2:13][CH2:12]2)[CH3:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of chlorosulfonic acid (0.48 mL) in dichloromethane (5 mL) at 0° C. was added dropwise a solution of 1-(6-ethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2,2,2-trifluoro-ethanone (0.39 g, 1.43 mmol). The mixture was stirred at room temperature overnight before partitioning between water and dichloromethane. The organic layer was removed, dried over sodium sulfate, filtered and evaporated to dryness yielding the subtitled compound as a clear oil (0.34 g). 1H NMR δ (CDCl3) 1.46-1.63 (3H, t), 2.95-3.06 (2H, m), 3.80-3.95 (2H, m), 4.18-4.32 (2H, m), 4.69-4.80 (2H, d), 6.84-6.93 (1H, d), 7.70-7.79 (1H, d).