4-(4-Methylsulfonylphenyl)benzoic acid → N-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)-4'-(methylsulfonyl)[1,1'-biphenyl]-4-carboxamide
Reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[CH3:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][C:30]([C:33](O)=[O:34])=[CH:29][CH:28]=2)=[CH:23][CH:22]=1)(=[O:20])=[O:19]>>[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:33]([C:30]4[CH:29]=[CH:28][C:27]([C:24]5[CH:25]=[CH:26][C:21]([S:18]([CH3:17])(=[O:20])=[O:19])=[CH:22][CH:23]=5)=[CH:32][CH:31]=4)=[O:34])=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1Participants
3
Procedure
Conducting the operations similar to those of Example 1 using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 4′-(methylsulfonyl)[1,1′-biphenyl]-4-carboxylic acid, the title compound was obtained as white solid.
Sources & evidence
- ORD record
- ord-b05bc350b84b43b582635aa0845d7bf0
- Source dataset
- uspto-grants-2009_03