(Pyrimidin-5-yl)boronic acid → HCID 16118958, compound
Reaction equation
Br[C:2]1[CH:11]=[N:10][C:9](Cl)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[N:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[N:15][CH:14]=1.[NH2:22][C:23]1[N:24]=[C:25]([CH3:28])[S:26][CH:27]=1>>[CH3:28][C:25]1[S:26][CH:27]=[C:23]([NH:22][C:9]2[N:10]=[CH:11][C:2]([C:17]3[CH:18]=[N:13][CH:14]=[N:15][CH:16]=3)=[C:3]3[C:8]=2[N:7]=[CH:6][CH:5]=[CH:4]3)[N:24]=1Participants
4
Procedure
The title compound, MS: m/e=321.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 5-bromo-8-chloro-[1,7]naphthyridine (Example H), 5-pyrimidineboronic acid and 4-amino-2-methylthiazole (Example F).
Sources & evidence
- ORD record
- ord-3427cc8164f7400fbf0bb2b25b3f21cf
- Source dataset
- uspto-grants-2009_03