1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one → 2-[2-[2-(4-Chlorophenyl)-5-methoxy-phenyl]-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid
Reaction equation
[Cl:1][C:2]1[CH:48]=[CH:47][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22]5[N:26]([CH:27]6[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]6)[C:25]6[CH:33]=[CH:34][C:35]([C:37]([OH:39])=[O:38])=[CH:36][C:24]=6[N:23]=5)[CH:18]=4)[N:13]=3)=[CH:10][C:9](C(N3CCCC3)=O)=[CH:8][CH:7]=2)=[CH:4][CH:3]=1.C[C:50](C1C=C(OC)C=CC=1O)=[O:51]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22]5[N:26]([CH:27]6[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]6)[C:25]6[CH:33]=[CH:34][C:35]([C:37]([OH:39])=[O:38])=[CH:36][C:24]=6[N:23]=5)[CH:18]=4)[N:13]=3)=[CH:10][C:9]([O:51][CH3:50])=[CH:8][CH:7]=2)=[CH:47][CH:48]=1Participants
3
Reactant 2
Product 1
Procedure
The title compound was synthesized in seven steps as described for Compound 204 except 2-hydroxy-5-methoxy acetophenone was used instead of Compound 18.