Pyridine → HCID 13770523, compound

Reaction equation

[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([OH:12])=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:13])[CH3:2].N1C=CC=CC=1.[Cl:20][CH2:21][C:22](Cl)=[O:23]>ClCCl>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][C:8]([O:12][C:22](=[O:23])[CH2:21][Cl:20])=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:13])[CH3:2]

Participants

Procedure

To a slurry of 100 g. (0.565 mole) of 1-ethyl-5-hydroxyoxindole in 91.3 ml. (1.13 moles) of pyridine and 565 ml. of dichloromethane at 0° C. was added dropwise a solution of 89.3 ml. (1.13 moles) of chloroacetyl chloride in 100 ml. of dichloromethane. The reaction mixture was allowed to stir for 15 minutes, and was then added to 1 l. of ice cold 2N hydrochloric acid and 500 ml. of dichloromethane. The aqueous layer was extracted once again with 300 ml. of dichloromethane and the combined organic extracts washed once with 500 ml. of a saturated brine solution, dried over magnesium sulfate and concentrated to give the desired product in quantitative yield. A small sample was crystallized from hexane, m.p. 53°-57° C.