6-Bromo-4-chloroquinoline → HCID 58665980, compound

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2Cl.Cl.[CH3:14][O:15][C@@H:16]1[C@@H:20]([O:21][CH3:22])[CH2:19][NH:18][CH2:17]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[N:18]1[CH2:19][C@H:20]([O:21][CH3:22])[C@@H:16]([O:15][CH3:14])[CH2:17]1

Participants

Reactant 2

HCID 51395376-Bromo-4-chloroquinoline

HCID 23537231trans-3,4-Dimethoxypyrrolidine hydrochloride

Product 1

HCID 58665980HCID 58665980, compoundYield 35.7%

Procedure

697 mg 6-bromo-4-chloroquinoline and 482 mg (3S,4S)-3,4-dimethoxytetrahydro-1H pyrrole monohydrochloride were reacted by the same method as in Production Example 82, to give 346 mg of the title compound as pale brown crystals.

Sources & evidence

ORD record: ord-89fd9da20ba146b4ac2f3d471bf591bc
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07074801B1

Reaction notes

Loading…