(4-Fluorophenyl)(piperidin-4-yl)methanol → HCID 9924146, compound
Reaction equation
Br[CH2:2][CH2:3][CH:4]([NH:11]C(OC(C)(C)C)=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[OH:27])=[CH:22][CH:21]=1>>[NH2:11][CH:4]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[CH2:3][CH2:2][N:31]1[CH2:32][CH2:33][CH:28]([CH:26]([C:23]2[CH:22]=[CH:21][C:20]([F:19])=[CH:25][CH:24]=2)[OH:27])[CH2:29][CH2:30]1Participants
3
Procedure
The procedure given in Example 2 was followed using 3-bromo-1-(tert-butoxycarbonyl)amino-1-phenyl propane and (4-fluorophenyl)-piperidin-4-yl-methanol as reactants, instead of d-1-bromo-2-(tert-butoxycarbonyl)amino-3-phenyl propane and hexamethyleneimine to give [1-(3-Amino-3-phenyl-propyl)-piperidin-4-yl]-(4-fluoro-phenyl)-methanol.
Sources & evidence
- ORD record
- ord-00b0281c50da4bacb5aa3150161bb91c
- Source dataset
- uspto-grants-2006_07
- Patent number
- US07078537B2