Methyl iodide → HCID 22174876, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:12]=[CH:11][N:10]=[C:9]([SH:13])[N:8]=1.[C:14](=O)([O-])[O-].[Na+].[Na+].IC>CC(C)=O>[CH3:14][S:13][C:9]1[N:8]=[C:7]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[N:12]=[CH:11][N:10]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred suspension of the product of step 1 (0.707 g, 3.72 mmol) in acetone (36 mL) was added sodium carbonate (0.79 g, 7.5 mmol) followed by iodomethane (0.35 mL, 5.6 mmol). After overnight stirring, the reaction was filtered free of undissolved solid and concentrated to afford product as light brown solid: 1H NMR (DMSO-d6) δ 9.13 (s, 1H), 8.84–8.76 (m, 1H), 8.55–8.43 (m, 1H), 8.11–8.00 (m, 1H), 7.69–7.60 (m, 1H), 2.63 (s, 3H) ppm.
Workup
- filtrationthe reaction was filtered free of undissolved solid
- concentrationconcentrated
- customto afford product as light brown solid
Sources & evidence
- ORD record
- ord-0dc708d3d3ad4ba0856ae0336b210295
- Source dataset
- uspto-grants-2006_04
- Patent number
- US07034031B2
Reaction notes
Loading…