Morpholine-3,5-dione → 4-[2-(2-Bromophenyl)ethyl]morpholine-3,5-dione

HRID 1797296Notes

Reaction equation

HRID 1797296 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5]O.[NH:11]1[C:16](=[O:17])[CH2:15][O:14][CH2:13][C:12]1=[O:18].BrC1C=CC=CC=1CCN1C(=O)CN(C)C1=O>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][N:11]1[C:16](=[O:17])[CH2:15][O:14][CH2:13][C:12]1=[O:18]

Participants

4

Reactant 3

HCID 364836Morpholine-3,5-dioneHCID 27340892-(2-Bromophenyl)ethan-1-olHCID 98573943-[2-(2-Bromophenyl)ethyl]-1-methylimidazolidine-2,4-dione

Product 1

HCID 98793064-[2-(2-Bromophenyl)ethyl]morpholine-3,5-dione

Procedure

2-Bromophenethyl alcohol (402 mg, 2 mmol) and morpholine-3,5-dione (322 mg, 2.8 mmol) were treated as described in the preparation of compound 436. Purification was done by flash chromatography (petroleum ether/ethyl acetate 4:1) to provide the title compound as a colorless solid.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-436f54ac426e448aa060a1c0a459eee7
Source dataset
uspto-grants-2006_04
Patent number
US07034015B2

Reaction notes

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