Glutarimide → 1-[2-(2-Bromophenyl)ethyl]piperidine-2,6-dione

HRID 1797297Notes

Reaction equation

HRID 1797297 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5]O.[C:11]1(=[O:18])[NH:16][C:15](=[O:17])[CH2:14][CH2:13][CH2:12]1.BrC1C=CC=CC=1CCN1C(=O)CN(C)C1=O>>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][N:16]1[C:11](=[O:18])[CH2:12][CH2:13][CH2:14][C:15]1=[O:17]

Participants

4

Reactant 3

HCID 70726GlutarimideHCID 27340892-(2-Bromophenyl)ethan-1-olHCID 98573943-[2-(2-Bromophenyl)ethyl]-1-methylimidazolidine-2,4-dione

Product 1

HCID 99659641-[2-(2-Bromophenyl)ethyl]piperidine-2,6-dione

Procedure

2-Bromophenethyl alcohol (402 mg, 2 mmol) and glutarimide (317 mg, 2.8 mmol) were treated as described in the preparation of compound 436. Purification was done by flash chromatography (petroleum ether/ethyl acetate 2:1) to provide the title compound as a colorless solid.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-6775be51e7b949f590d83bb994f20fc5
Source dataset
uspto-grants-2006_04
Patent number
US07034015B2

Reaction notes

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