1-Butylpiperazine → HCID 46852139, compound

HRID 1797941

Reaction equation

HRID 1797941 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][S:13]([C:16]3[CH:21]=[CH:20][C:19]([NH:22][C:23]([NH:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([C:32]#[N:33])[CH:27]=4)=[O:24])=[CH:18][CH:17]=3)(=[O:15])=[O:14])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:34]([N:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1)[CH2:35][CH2:36][CH3:37]>>[CH2:34]([N:38]1[CH2:43][CH2:42][N:41]([C:32](=[NH:33])[C:28]2[CH:27]=[C:26]([NH:25][C:23](=[O:24])[NH:22][C:19]3[CH:20]=[CH:21][C:16]([S:13]([NH:12][C:6]4[C:5]5[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=5)[N:9]=[CH:8][CH:7]=4)(=[O:14])=[O:15])=[CH:17][CH:18]=3)[CH:31]=[CH:30][CH:29]=2)[CH2:40][CH2:39]1)[CH2:35][CH2:36][CH3:37]

Participants

3

Reactant 2

HCID 4243221-ButylpiperazineHCID 57504195N-(7-chloroquinolin-4-yl)-4-(3-(3-cyanophenyl)ureido)benzenesulfonamide

Product 1

HCID 46852139HCID 46852139, compoundYield 25%

Procedure

The title compound was prepared from N-(7-chloroquinolin-4-yl)-4-(3-(3-cyanophenyl)ureido)benzenesulfonamide following procedure C and using 2.2 equivalents of n-butylpiperazine as secondary amine. The product was purified by preparative HPLC.

Workup

  1. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-d8ccbdb214894d91b5fcf131790220c9
Source dataset
uspto-grants-2013_01
Patent number
US08343963B2

Linked notes

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