2,2-Difluoroethanamine → N-{2-[(2,2-Difluoroethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamide

HRID 1799283

Reaction equation

HRID 1799283 reaction equation
[F:1][C:2]([F:32])([F:31])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([NH:15][C:16](=[O:30])[C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:19][CH:18]=2)[C:12]([OH:14])=O)=[CH:6][CH:5]=1.[F:33][CH:34]([F:37])[CH2:35][NH2:36]>>[F:33][CH:34]([F:37])[CH2:35][NH:36][C:12](=[O:14])[CH:11]([NH:15][C:16](=[O:30])[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][C:26]([F:27])([F:28])[F:29])=[CH:19][CH:18]=1)[CH2:10][C:7]1[CH:6]=[CH:5][C:4]([O:3][C:2]([F:32])([F:31])[F:1])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 1362742,2-DifluoroethanamineHCID 780686233-[4-(Trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid

Product 1

HCID 57972095N-{2-[(2,2-Difluoroethyl)amino]-2-oxo-1-[4-(trifluoromethoxy)benzyl]ethyl}-4-(3,3,3-trifluoropropoxy)benzamideYield 80.9%

Procedure

A reaction similar to that described in Example 32 (32c) was conducted using 3-[4-(trifluoromethoxy)phenyl]-2-{[4-(3,3,3-trifluoropropoxy)benzoyl]amino}propanoic acid (233 mg) prepared in Example 70 (70a) and 2,2-difluoroethylamine (49 mg) to give 214 mg of the title compound (white powder).

Workup

  1. customA reaction similar to

Sources & evidence

ORD record
ord-fd50158923be47fdb6e1e13c46603f1e
Source dataset
uspto-grants-2013_01
Patent number
US08344029B2

Linked notes

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