Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:27])[C:10](=[O:26])[N:11]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH3:25])[C:12]=2[C:16]([O:18]C)=[O:17])[C:7]1=[O:28].[OH-].[K+].O1CCCC1CO.O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:29]=[CH:30][C:31]=1[F:32])[CH2:5][N:6]1[CH2:15][CH2:14][C:13]2[C:8](=[C:9]([OH:27])[C:10](=[O:26])[N:11]([CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH3:25])[C:12]=2[C:16]([OH:18])=[O:17])[C:7]1=[O:28]Participants
4
Reactant 3
Product 1
Conditions
- Temperature
- 50 °C
Procedure
Methyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-[4-(methylamino)butyl]-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate (0.18 g, 0.38 mmol) and potassium hydroxide (0.17 g, 2.3 mmol) in a mixture of 1:1:1 v/v/v tetrahydrofuran-methanol-water (4.5 mL) was heated at 50° C. overnight. The reaction mixture was concentrated under vacuum. The residue was partitioned between dichloromethane and dilute hydrochloric acid. The aqueous extract was concentrated under vacuum to provide the title compound as hydrochloride salt. This was used in the following step without further purification. ES MS M+1=452
Workup
- concentrationThe reaction mixture was concentrated under vacuum
- customThe residue was partitioned between dichloromethane and dilute hydrochloric acid
- extractionThe aqueous extract
- concentrationwas concentrated under vacuum
Sources & evidence
- ORD record
- ord-edb76f37641c463b8fafa3e58110303d
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07741315B2
Linked notes
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