1,4-Dioxane hydrochloride → 1-Methyl-3-pyrrolidinaMine 2HCl

Reaction equation

[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([NH:7]C(OC(C)(C)C)=O)[CH2:3]1.[ClH:15].O1CCOCC1>>[ClH:15].[ClH:15].[CH3:1][N:2]1[CH2:6][CH2:5][CH:4]([NH2:7])[CH2:3]1

Participants

Reactant 2

HCID 204431481,4-Dioxane hydrochloride

HCID 23544388tert-Butyl (1-methylpyrrolidin-3-yl)carbamate

Product 1

HCID 457922541-Methyl-3-pyrrolidinaMine 2HCl

Procedure

The prepared N-methyl-3-t-butoxycarbonylaminopyrrolidine (1.8 g, 8.9 mmoles) is dissolved in HCl/dioxane (4N, 44 mL, 256 mmoles) and allowed to stir at RT for 45 min. The dioxane is removed by concentration and N-methyl-3-aminopyrrolidine dihydrochloride salt is dried under high vacuum (1.7 g).

Workup

customThe dioxane is removed by concentration and N-methyl-3-aminopyrrolidine dihydrochloride salt
customis dried under high vacuum (1.7 g)

Sources & evidence

ORD record: ord-0ef90fe745574f97a4c1c9bd9b028c38
Source dataset: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08349839B2

Reaction notes

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