Ethyl 4-iodobenzoate → (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803973

Reaction equation

HRID 1803973 reaction equation
I[C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[CH:4][CH:3]=1.[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[N:15]1[C:2]1[CH:3]=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 142891Ethyl 4-iodobenzoateHCID 2734858(R)-4-Methyloxazolidin-2-one

Product 1

HCID 58484719(R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

Procedure

By reaction and treatment in the same manner as in Preparation Example 18 and using ethyl 4-iodobenzoate (1.4 mL) and (R)-4-methyloxazolidin-2-one (860 mg) described in Preparation Example 25, the title compound (0.9 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 18
  3. customdescribed in Preparation Example 25

Sources & evidence

ORD record
ord-e84e8c1253ee489a82819b91954e3aab
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Linked notes

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