(R)-4-Methyloxazolidin-2-one → (R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid

HRID 1803979

Reaction equation

HRID 1803979 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].[CH3:14][C@@H:15]1[CH2:19][O:18][C:17](=[O:20])[NH:16]1>>[CH3:13][O:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:16]1[C@H:15]([CH3:14])[CH2:19][O:18][C:17]1=[O:20])[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 14570117Methyl 4-bromo-3-methoxybenzoate

Product 1

HCID 58484801(R)-3-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acidYield 97.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 45 and using methyl 4-bromo-3-methoxybenzoate (1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 45
  3. customdescribed in Preparation Example 25

Sources & evidence

ORD record
ord-dfc5d763c3244908b695e300cb61484a
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Linked notes

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