(R)-4-Methyloxazolidin-2-one → methyl (R)-3-methyl-4-(4-methyl-2-oxooxazolidin-3-yl)benzoate

HRID 1804029

Reaction equation

HRID 1804029 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH3:12].[CH3:13][C@@H:14]1[CH2:18][O:17][C:16](=[O:19])[NH:15]1>>[CH3:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[N:15]1[C@H:14]([CH3:13])[CH2:18][O:17][C:16]1=[O:19])[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 2734858(R)-4-Methyloxazolidin-2-oneHCID 3294148Methyl 4-bromo-3-methylbenzoate

Product 1

HCID 58484849methyl (R)-3-methyl-4-(4-methyl-2-oxooxazolidin-3-yl)benzoateYield 100.3%

Procedure

By reaction and treatment in the same manner as in Preparation Example 12 and using methyl 4-bromo-3-methylbenzoate (1.1 g) and (R)-4-methyloxazolidin-2-one (607 mg) described in Preparation Example 25, the title compound (1.2 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 12
  3. customdescribed in Preparation Example 25

Sources & evidence

ORD record
ord-2633152adc6e4e22b3eb0d9ed530f9c3
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Linked notes

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