4-Bromo-2-fluorobenzoic acid → (4-Bromo-2-fluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804128Notes

Reaction equation

HRID 1804128 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][C:13]1[CH:14]=[CH:15][C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:16]3[CH:15]=[CH:14][C:13]([CH3:12])=[CH:18][N:17]=3)[CH2:20][CH2:21]2)=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

3

Reactant 2

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 114807791-(5-Methyl-2-pyridinyl)piperazine

Product 1

HCID 58484600(4-Bromo-2-fluorophenyl)[4-(5-methylpyridin-2-yl)piperazin-1-yl]methanoneYield 88.9%

Procedure

By reaction and treatment in the same manner as in Preparation Example 90 and using 4-bromo-2-fluorobenzoic acid (1.45 g) and 1-(5-methylpyridin-2-yl)piperazine (1.06 g) described in Preparation Example 183, the title compound (2.01 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 90
  3. customdescribed in Preparation Example 183

Sources & evidence

ORD record
ord-473bee038c0a495ea5ae79571b1e382e
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…